主动脉夹层
DMT1型
下调和上调
信号转导
细胞生物学
化学
医学
生物
心脏病学
主动脉
基因
生物化学
运输机
作者
Qiang Xie,Jianji Wang,Runqiao Li,Hao Liu,Yongliang Zhong,Qinfeng Xu,Yipeng Ge,Chengnan Li,Li‐Zhong Sun,Jun‐Ming Zhu
摘要
Aortic dissection (AD), caused by tearing of the intima and avulsion of the aortic media, is a severe threat to patient life and organ function. Iron is closely related to dissection formation and organ injury, but the mechanism of iron ion transport disorder in endothelial cells (ECs) remains unclear. We identified the characteristic EC of dissection with iron overload by single-cell RNA sequencing data. After intersecting iron homeostasis and differentially expressed genes, it was found that hypoxia-inducible factor-1α (HIF-1α) and divalent metal transporter 1 (DMT1) are key genes for iron ion disorder. Subsequently, IL-6R was identified as an essential reason for the JAK-STAT activation, a classical iron regulation pathway, through further intersection and validation. In
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