化学
降级(电信)
反褶积
泛素连接酶
电流(流体)
蛋白质降解
生物化学
计算生物学
生物物理学
生化工程
泛素
热力学
算法
计算机科学
电信
物理
生物
工程类
基因
作者
Yufeng Xiao,Yaxia Yuan,Yi Liu,Zongtao Lin,Guangrong Zheng,Daohong Zhou,Dongwen Lv
标识
DOI:10.1021/acs.jmedchem.4c00723
摘要
Targeted protein degradation (TPD), including the use of proteolysis-targeting chimeras (PROTACs) and molecular glue degraders (MGDs) to degrade proteins, is an emerging strategy to develop novel therapies for cancer and beyond. PROTACs or MGDs function by inducing the proximity between an E3 ligase and a protein of interest (POI), leading to ubiquitination and consequent proteasomal degradation of the POI. Notably, one major issue in TPD is the lack of ligandable E3 ligases, as current studies predominantly use CUL4
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