亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Association of Incident Cardiovascular Disease With Time Course and Cumulative Exposure to Multiple Risk Factors

医学 风险因素 累积发病率 入射(几何) 血压 风险评估 疾病 冲程(发动机) 无症状的 脉冲压力 内科学 心脏病学 队列 机械工程 物理 计算机安全 计算机科学 光学 工程类
作者
Michaël Domanski,Colin O. Wu,Xin Tian,Ahmed Hasan,Xiaoyang Ma,Yi Huang,Rui Miao,Jared P. Reis,Sejong Bae,Anwar Husain,David R. Jacobs,Norrina B. Allen,Mei‐Ling Ting Lee,Charles C. Hong,Michael E. Farkouh,Donald M. Lloyd‐Jones,Valentı́n Fuster
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:81 (12): 1151-1161 被引量:31
标识
DOI:10.1016/j.jacc.2023.01.024
摘要

The quantitative relationship of incident cardiovascular disease (CVD) to lifetime cumulative risk factor exposure is not well understood. Using CARDIA (Coronary Artery Risk Development in Young Adults) study data, we examined the quantitative associations of cumulative exposure over time to multiple, simultaneously operating risk factors with CVD incidence and the incidence of its components. Regression models were developed quantifying the influence of the time course and severity of multiple CVD risk factors, operating simultaneously, on risk of incident CVD. The outcomes were incident CVD and the incidence of its components: coronary heart disease, stroke, and congestive heart failure. Our study included 4,958 asymptomatic adults enrolled in CARDIA from 1985 to 1986 (ages 18 to 30 years) who were followed for 30 years. Risk of incident CVD depends on the time course and severity of a series of independent risk factors, the impact of which is mediated by their effects on individual CVD components after age 40 years. Cumulative exposure (AUC vs time) to low-density lipoprotein cholesterol and triglycerides was independently associated with risk of incident CVD. Of the blood pressure variables, areas under the mean arterial pressure vs time curve and the pulse pressure vs time curve were strongly and independently associated with incident CVD risk. The quantitative description of the link between risk factors and CVD informs the construction of individualized CVD mitigation strategies, design of primary prevention trials, and assessment of public health impact of risk factor-based interventions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
量子星尘发布了新的文献求助10
9秒前
31秒前
35秒前
Dandelion完成签到,获得积分10
43秒前
58秒前
完美世界应助nsc采纳,获得10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
所所应助nsc采纳,获得10
1分钟前
小蘑菇应助nsc采纳,获得50
1分钟前
Ava应助nsc采纳,获得10
1分钟前
隐形曼青应助nsc采纳,获得10
1分钟前
慕青应助nsc采纳,获得10
1分钟前
脑洞疼应助nsc采纳,获得10
1分钟前
善学以致用应助nsc采纳,获得10
1分钟前
ding应助nsc采纳,获得30
1分钟前
Hello应助nsc采纳,获得10
1分钟前
烟花应助nsc采纳,获得10
1分钟前
1分钟前
1分钟前
漫步随心完成签到,获得积分20
2分钟前
NexusExplorer应助科研通管家采纳,获得10
2分钟前
2分钟前
今后应助nsc采纳,获得10
2分钟前
bkagyin应助nsc采纳,获得10
2分钟前
小二郎应助nsc采纳,获得10
2分钟前
Jasper应助nsc采纳,获得10
2分钟前
李爱国应助nsc采纳,获得10
2分钟前
脑洞疼应助nsc采纳,获得10
2分钟前
慕青应助nsc采纳,获得10
2分钟前
天天快乐应助nsc采纳,获得10
2分钟前
Akim应助nsc采纳,获得10
2分钟前
充电宝应助nsc采纳,获得10
2分钟前
量子星尘发布了新的文献求助30
3分钟前
3分钟前
3分钟前
3分钟前
3分钟前
3分钟前
3分钟前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3957061
求助须知:如何正确求助?哪些是违规求助? 3503084
关于积分的说明 11111255
捐赠科研通 3234121
什么是DOI,文献DOI怎么找? 1787751
邀请新用户注册赠送积分活动 870762
科研通“疑难数据库(出版商)”最低求助积分说明 802264