In the past 20 years since The Lancet Neurology was launched, the number of publications about traumatic brain injury has steadily increased. The first paper published in the journal two decades ago was a Review on the use of bone marrow stromal cells to treat neural injury.1 In 2022, six original research Articles have been published in the journal, including two in this issue reporting on biomarkers of prognosis. All these publications mirror the increasing recognition of traumatic brain injury as a serious public health problem, which afflicts roughly 55 million people worldwide2 and has a cost of at least US$400 billion per year.