GSH-Triggered NO releasing nanoplatform based on a covalent organic framework for “1 + 1 > 2” synergistic cancer therapy

A porphyrin containing covalent organic framework (COF) was developed as the glutathione responsive nitric oxide (NO) donor delivery nanoplatform for "1 + 1 > 2" synergistic cancer therapy of NO mediated therapy and photodynamic therapy.