支气管扩张
医学
免疫学
恶化
病理生理学
流感嗜血杆菌
粘液纤毛清除率
先天免疫系统
慢性感染
免疫系统
炎症
微生物学
病理
肺
抗生素
内科学
生物
作者
Belén Solarat,Lídia Perea,Rosa Faner,David de la Rosa,Miguel Ángel Martínez‐García,Oriol Sibila
标识
DOI:10.1016/j.arbres.2022.09.004
摘要
Bronchiectasis is a complex and heterogeneous disease. Its pathophysiology is poorly understood, but chronic bronchial infection plays an important role in its natural history, and is associated with poor quality of life, more exacerbations and increased mortality. Pseudomonas aeruginosa, Haemophilus influenzae and Staphylococcus aureus are the most common bacteria related to chronic bronchial infection. Non-tuberculous mycobacteria, fungi and respiratory viruses are also present during clinical stability, and may increase the risk of acute exacerbation. Chronic inflammation is present in bronchiectasis, especially neutrophilic inflammation. However, macrophages and eosinophils also play a key role in the disease. Finally, airway epithelium has innate mechanisms such as mucociliary clearance and antibacterial molecules like mucins and antimicrobial peptides that protect the airways from pathogens. This review addresses how the persistence of microorganisms in the airways and the imbalance of the immune system contribute to the development of chronic bronchial infection in bronchiectasis.
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