Liquid Biopsy Analysis as a Tool for TKI-Based Treatment in Non-Small Cell Lung Cancer

液体活检 肺癌 ROS1型 医学 靶向治疗 活检 肿瘤科 循环肿瘤细胞 胎儿游离DNA 癌症 内科学 癌症研究 腺癌 生物 转移 怀孕 胎儿 产前诊断 遗传学
作者
Karolina Buszka,Aliki Ntzifa,Barbara Owecka,Paula Kamińska,Agata Kolecka-Bednarczyk,M. Zabel,Michał Nowicki,Evi Lianidou,Joanna Budna
出处
期刊:Cells [MDPI AG]
卷期号:11 (18): 2871-2871 被引量:8
标识
DOI:10.3390/cells11182871
摘要

The treatment of non-small cell lung cancer (NSCLC) has recently evolved with the introduction of targeted therapy based on the use of tyrosine kinase inhibitors (TKIs) in patients with certain gene alterations, including EGFR, ALK, ROS1, BRAF, and MET genes. Molecular targeted therapy based on TKIs has improved clinical outcomes in a large number of NSCLC patients with advanced disease, enabling significantly longer progression-free survival (PFS). Liquid biopsy is an increasingly popular diagnostic tool for treating TKI-based NSCLC. The studies presented in this article show that detection and analysis based on liquid biopsy elements such as circulating tumor cells (CTCs), cell-free DNA (cfDNA), exosomes, and/or tumor-educated platelets (TEPs) can contribute to the appropriate selection and monitoring of targeted therapy in NSCLC patients as complementary to invasive tissue biopsy. The detection of these elements, combined with their molecular analysis (using, e.g., digital PCR (dPCR), next generation sequencing (NGS), shallow whole genome sequencing (sWGS)), enables the detection of mutations, which are required for the TKI treatment. Despite such promising results obtained by many research teams, it is still necessary to carry out prospective studies on a larger group of patients in order to validate these methods before their application in clinical practice.

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