光热治疗
二硒醚
生物相容性
材料科学
纳米技术
近红外光谱
光热效应
体内
光学
生物
物理
生物技术
冶金
硒
作者
Hanhan Xie,Shengyong Geng,Jundong Shao,Guanghong Luo,Qian Liu,Jiahong Wang,Yue Chen,Paul K. Chu,Zhibin Li,Xue‐Feng Yu
标识
DOI:10.1002/adhm.202202126
摘要
Abstract As a prominent class of 2D transition metal dichalcogenides (TMDCs), niobium diselenide nanosheets (NbSe 2 NSs) have garnered tremendous interest on account of promising applications pertaining to optoelectronics and energy storage. Although NbSe 2 NSs have many unique advantages such as inherent biocompatibility and broad absorption in the NIR region, their biomedical applications have rarely been reported, especially as therapeutic agents for the second near‐infrared (NIR‐II) range. Herein, a biodegradable nanotherapeutic platform consisting of NbSe 2 NSs is designed and demonstrated for NIR‐II light‐triggered photothermal therapy. NbSe 2 NSs synthesized by grinding and liquid exfoliation exhibit superior photothermal conversion efficiency (48.3%) and remarkable photothermal stability in the NIR‐II region. In vitro assessment demonstrates that NbSe 2 NSs have favorable photothermal cell ablation efficiency and biocompatibility. After intravenous injection in vivo, the NbSe 2 NSs accumulate passively in tumor sites to facilitate fluorescence imaging and tumor ablation by NIR‐II illumination. Furthermore, as a result of gradual degradation in the physiological environment, NbSe 2 NSs can be excreted from the body to avoid potential toxicity caused by long‐term retention in vivo. The results reveal a promising NIR‐II light‐triggered PTT strategy with the aid of NbSe 2 NSs and the platform is expected to have large potential in cancer theranostics.
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