肢端肥大症
生长抑素
生长激素
医学
临床实习
胰岛素样生长因子
不利影响
胰岛素
重组DNA
内科学
临床意义
激素
生长激素缺乏
生物信息学
内分泌学
生长因子
生物
生物化学
受体
基因
家庭医学
作者
Zdeněk Fryšák,Jan Schovánek,Maurizio Iacobone,David Karásek
摘要
Interest in growth hormone (GH) is inextricably linked to the need for in depth understanding of the somatomedins (insulin-like growth factors) which are polypeptides structurally similar to insulin and with broad physiological activity. To date, the most commonly known is Insulin-Like Growth Factor I (IGF-I). Despite considerable current knowledge of IGF-I, however, its bioactivity is incompletely understood. Measurement of IGF-I is of the utmost importance in the diagnosis and treatment of, for example acromegaly and growth hormone deficiency. The development of recombinant IGF-I, has allowed its use in such cases. Clinical practice, however, shows that few young/adult patients will benefit from treatment with the rIGF-I, mecasermin, given the number of adverse effects found. This review focuses on current knowledge mainly related to IGF-I and the use of its recombinant form (rIGF-I) in clinical practice. Several functions of IGI-II have been elucidated but their clinical significance is unclear.
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