Preventing Alzheimer's disease is difficult

Alzheimer's disease is devastating for the individual, family, and society. Prevention of this disease, or halting it in the early stages of progression, is imperative. Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directionsInterventions that have even quite modest effects at the individual level could drastically reduce the future burden of dementia associated with Alzheimer's disease at the population level. In the past three decades, both pharmacological and lifestyle interventions have been studied for the prevention of cognitive decline or dementia in randomised controlled trials of individuals mostly aged older than 50–55 years with or without risk factors for Alzheimer's disease. Several trials testing the effects of physical activity, cognitive training, or antihypertensive interventions showed some evidence of efficacy on a primary cognitive endpoint. Full-Text PDF