Abstract 15940: Wall Shear Stress and Vorticity in Atrial Fibrillation, Pulmonary Hypertension, and Normal Atrial Anatomy Models

医学 心脏病学 心房颤动 内科学 涡度 舒张期 血流 剪应力 肺动脉高压 血压 机械 涡流 物理
作者
David Rutkowski,Alexey V. Glukhov,Alejandro Roldán‐Alzate
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:142 (Suppl_3)
标识
DOI:10.1161/circ.142.suppl_3.15940
摘要

Introduction: Atrial fibrillation (AF) is a common cardiac rhythm disorder that is often comorbid with pulmonary hypertension (PH) and other conditions associated with abnormal atrial pressure and/or volume overload. In the setting of atrial dilation, mechanoelectric feedback has been linked to the development of ectopic beats that trigger paroxysmal AF mainly originating from pulmonary veins (PVs). However, the precise mechanisms remain poorly understood. Here, we aimed to characterize atrial wall shear stress (WSS) and vorticity in the left atrium of AF, healthy, and at-risk for AF (PH) patient models to develop predictors of AF risk. Methods: Magnetic resonance imaging and computed tomography data (10 AF, 10 PH, and 10 healthy volunteers) were obtained retrospectively. The left atria were manually segmented from each data set. Four-dimensional flow MRI was performed on one patient to derive PV flow data. The 30 atrial geometries and PV flow conditions were used to run numerical blood flow simulations, and atrial WSS and blood flow vorticity were analyzed. Results: As seen in Figure 1, wall shear stress was highest near the PV roots and on the posterior atrial wall, the most common sources of AF triggers. Average WSS and vorticity were significantly lower in PH patients than in both the healthy (p=0.003(WSS), p=0.011(vorticity)) and AF (p=0.046(WSS), p=0.069(vorticity)) groups. Both WSS (r=-0.66) and vorticity (r=-0.68) were moderately correlated to atrial volume in the PH group. Atrial volume was significantly larger in PH (p<0.001) and AF (p<0.001) groups than in the healthy group. Conclusions: The larger atrial volumes of PH and AF patients lead to altered flow profiles and less frequently flow jet impingement on the atrial wall models, leading to abnormal vorticity and WSS profiles. These long term flow abnormalities may influence the development and/or localization of electrical abnormalities and AF; although further study is needed to confirm this hypothesis.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研混子发布了新的文献求助10
刚刚
egg发布了新的文献求助10
刚刚
1秒前
FashionBoy应助刘娟采纳,获得10
1秒前
hades发布了新的文献求助10
1秒前
嗯嗯完成签到,获得积分10
2秒前
wanci应助超A采纳,获得10
3秒前
3秒前
3秒前
3秒前
Sandy发布了新的文献求助20
3秒前
SciGPT应助嗒嗒嗒薇采纳,获得10
3秒前
3秒前
4秒前
5秒前
5秒前
serendipity发布了新的文献求助10
6秒前
北海发布了新的文献求助10
6秒前
charles发布了新的文献求助10
6秒前
7秒前
我是月球上的完成签到,获得积分10
8秒前
温柔皮皮虾完成签到,获得积分10
8秒前
ylh发布了新的文献求助10
8秒前
9秒前
月亮发布了新的文献求助10
10秒前
yu发布了新的文献求助10
11秒前
11秒前
潇洒冷雪完成签到,获得积分10
11秒前
11秒前
可爱的函函应助bubble采纳,获得30
11秒前
13秒前
13秒前
合适的芷巧完成签到,获得积分20
14秒前
苏素发布了新的文献求助10
14秒前
wanci应助科研通管家采纳,获得10
15秒前
上官若男应助科研通管家采纳,获得10
15秒前
SciGPT应助科研通管家采纳,获得10
15秒前
Carhao应助科研通管家采纳,获得10
15秒前
CipherSage应助科研通管家采纳,获得10
15秒前
我是老大应助科研通管家采纳,获得10
15秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
《粉体与多孔固体材料的吸附原理、方法及应用》(需要中文翻译版,化学工业出版社,陈建,周力,王奋英等译) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3083403
求助须知:如何正确求助?哪些是违规求助? 2736768
关于积分的说明 7542379
捐赠科研通 2386033
什么是DOI,文献DOI怎么找? 1265316
科研通“疑难数据库(出版商)”最低求助积分说明 613035
版权声明 597816