醋酸酐
亲核细胞
化学
催化作用
乙酰化
有机化学
溶剂
乙酰氯
酚类
生物化学
基因
作者
Naoures J. Eddine,Fayçal Jennen,Yakdhane Kacem,Jamil Kraı̈em
出处
期刊:Current organocatalysis
[Bentham Science]
日期:2020-07-31
卷期号:8 (2): 162-171
被引量:3
标识
DOI:10.2174/2213337207999200731184638
摘要
Background: Acetylation of protic nucleophiles is used to protect these functional groups. Most of the methods described in the literature use solvents, one or more equivalent of toxic bases or expensive and toxic catalysts. Therefore, new methodologies, above all, greener and more economical procedures, are still in demand. Objective: An eco-efficient method was developed for the acetylation of alcohols, phenols, thiols, amines, and carbohydrates, using acetic anhydride and a catalytic amount of the environmentally benign and inexpensive FeCl 3 .6H 2 O, under solvent-free conditions. Methods: Acetylation of a variety of protic nucleophiles was performed using 0.2 mol % of FeCl 3 .6H 2 O as the catalyst, and 1.2 equivalent of Ac 2 O as the acetylating agent at room temperature and under solvent-free conditions. Results: This procedure appears to be highly efficient and promoted rapid and quantitative acetylation under simple and minimum manipulation. Chromatography or recrystallization was generally not necessary for the purification of products. Conclusion: This eco-friendly protocol appears to be potentially universally applicable in organic design to protect protic nucleophiles and isscalable for industrial fields.
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