The expression and clinical significance of cell division cycle associated 5 in bladder cancer tissues

Objective To investigate the expression of cell division cycle associated 5 (CDCA5) in bladder cancer and its correlation with clinicopathological features. Methods Clinical data, bladder cancer tissues and adjacent normal tissue specimens of 56 patients undergoing radical cystectomy were collected. Immunohistochemical technique was used to detect the expression of CDCA5 in bladder cancer tissues and adjacent normal tissues, and the correlation between CDCA5 expression and clinicopathological features was analyzed. Results Immunohistochemistry showed that the high expression rate of CDCA5 in bladder cancer tissues was 60.7% (34/56), and the low expression rate was 39.3% (22/56). The high expression rate in normal tissues adjacent to cancer was 23.2% (13/56), and the low expression rate was 76.8% (43/56). The expression of CDCA5 in bladder cancer tissues and adjacent normal tissues was statistically significant (χ2=16.168, P 0.05), gender (χ2=0.049, P>0.05) The tumor diameter (χ2=0.443, P>0.05) and lymph node metastasis (χ2=0.225, P>0.05) were irrelevant. Conclusion CDCA5 is up-regulated in bladder cancer tissues and associated with increased clinical stage and pathological grade. It suggests that CDCA5 is associated with the occurrence, development, invasion and malignancy of bladder cancer. Key words: Bladder cancer; Cell division cycle associated 5; Clinicopathological features; Immunohistochemistry