Analysis on influencing factors on plasma homocysteine level in elderly people in Tianjin

Objective To investigate the influencing factors on serum homocysteine level in healthy retired-elderly people in Tianjin, in order to provide theoretical basis and guidance for clinical intervention therapy. Methods A total of 184 participants meeting the standard of Chinese healthy elderly people (2013) were selected from 1247 retired-elderly people who took healthy physical examination in three grade III-A hospitals in Tianjin from June to August in 2014. They were divided into two groups based on plasma Hcy level: hyper-homocystinemia group (≥15 μmol/L) and normal plasma Hcy level group (<15μmol/L). The influencing factors on plasma Hcy level were analyzed by multiple stepwise regression and logistic regression analysis. Results The proportion of healthy retired-elderly people accounted for 14.76%, with men at 82.61% and women at 17.39%, mean age (78.37±6.88) years. The Hcy level was higher in healthy males than in healthy females 〔(16.90±6.86) μmol/L vs. (12.89±5.97) μmol/L, P 0.05). Spearman correlation analysis showed that the level of serum Hcy was positively correlated with serum uric acid levels (P=0.000). Multiple stepwise regression and logistic regression analysis showed that age, gender and serum uric acid level were risk factors for plasma Hcy level in healthy elderly people. Conclusions Age, gender and serum uric acid level are risk factors for serum Hcy level in healthy elderly people. Key words: Cysteine; Healthy surveys; Risk factors