Progress on the study of dendritic cell differentiation and function of epigenetic regulation mechanisms

Dendritic cells are well known as the strongest specific antigen-presentation cells in vivo,which exert the effects of capturing,processing and presenting antigen,as well as sensitizing naive T cells.In recent years,researches have showed that epigenetic processes such as DNA methylation,histone modifications,chromatin remodeling,genomic imprinting and non-coding RNA can regulate the expression of some related genes which can also regulate the differentiation and function of dendritic cells.In this review,from DNA methylation,histone modification and non-coding RNA,we summarize the recent study of dendritic cell differentiation and function of epigenetic regulation mechanisms. Key words: Dendritic cell; DNA methylation; Histone modification; Non-coding RNA