促红细胞生成素肝细胞(Eph)受体
以法林
轴突引导
神经科学
EPH受体A2
轴突
细胞生物学
生物
信号转导
受体酪氨酸激酶
作者
Franco Weth,Artur Kania
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2020-01-01
卷期号:: 123-146
被引量:3
标识
DOI:10.1016/b978-0-12-814407-7.00006-7
摘要
Animal behavior and cognition arise as a result of the developmental wiring of neural circuits in which axonal growth cones are guided by specialized ligand–receptor systems. Given the high complexity of even the simplest connectomes, the number of different guidance molecules is minute. This small number of genetically encoded cues generates most of the complexity of neuronal wiring through its deployment in sophisticated qualitative and quantitative combinations, much like the limited repertoire of notes gives rise to the prodigious richness of musical works. The ephrin/Eph system forms a major part of the guidance molecule repertoire. Its high versatility is due to variegated signaling options. These include the unique fact that ephrin/Eph signaling can operate in two fundamentally different ways, in a binary or a proportional mode. The binary mode operates when one of the two possible guidance alternatives is selected. The proportional mode, in contrast, allows for distinguishing thousands of subtly different addresses, such as those underlying somatotopic or retinotopic maps.
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