材料科学
生物相容性
分析物
超声波
生物医学工程
谐振器
纳米技术
智能材料
自愈水凝胶
声学
光电子学
化学
物理
医学
物理化学
高分子化学
冶金
作者
Navid Farhoudi,Hsuan-Yu Leu,Lars B. Laurentius,Jules J. Magda,Florian Solzbacher,Christopher F. Reiche
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2020-06-17
卷期号:5 (7): 1882-1889
被引量:20
标识
DOI:10.1021/acssensors.9b02180
摘要
One of the main challenges for implantable biomedical sensing schemes is obtaining a reliable signal while maintaining biocompatibility. In this work, we demonstrate that a combination of medical ultrasound imaging and smart hydrogel micromechanical resonators can be employed for continuous monitoring of analyte concentrations. The sensing principle is based on the shift of the mechanical resonance frequencies of smart hydrogel structures induced by their volume-phase transition in response to changing analyte levels. This shift can then be measured as a contrast change in the ultrasound images due to resonance absorption of ultrasound waves. This concept eliminates the need for implanting complex electronics or employing transcutaneous connections for sensing biomedical analytes in vivo. Here, we present proof-of-principle experiments that monitor in vitro changes in ionic strength and glucose concentrations to demonstrate the capabilities and potential of this versatile sensing platform technology.
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