双歧杆菌
动物双歧杆菌
双歧杆菌
短双歧杆菌
生物
基因型
放线菌科
益生菌
微生物学
长双歧杆菌
基因
遗传学
细菌
乳酸菌
作者
Zhujun He,Bo Yang,Xiaoming Liu,R. Paul Ross,Catherine Stanton,Jianxin Zhao,Hao Zhang,Wei Chen
标识
DOI:10.3168/jds.2020-19013
摘要
The oligosaccharide 2'-fucosyllactose (2'FL) in human breast milk selectively promotes the proliferation of bifidobacteria. One hundred fifty-one Bifidobacterium strains were evaluated for their capacity to utilize 2'FL based on the combination of phenotype and genotype association analysis. Through genotype analysis, 37 strains were predicted to have the ability to use 2'FL, including Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum ssp. longum, Bifidobacterium longum ssp. infantis, and Bifidobacterium dentium, whereas Bifidobacterium adolescentis, Bifidobacterium animalis, Bifidobacterium pseudocatenulatum, and Bifidobacterium angulatum could not use 2'FL. For in vitro utilization, there were noteworthy differences for 2'FL usage among different species, which were 100% consistent with genotype prediction. The results indicated that 2'FL utilization ability differed even within the same species, and Bifidobacterium followed the currently well-known pathway to utilize 2'FL, which could provide guidance to develop personalized prebiotics for different bifidobacteria via gene-trait matching analysis.
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