Enantioselective Radical Functionalization of Imines and Iminium Intermediates via Visible-Light Photoredox Catalysis

Abstract Visible-light photoredox catalysis has recently emerged as a powerful tool for the development of new and valuable chemical transformations under mild conditions. Visible-light promoted enantioselective radical transformations of imines and iminium intermediates provide new opportunities for the asymmetric synthesis of amines and the asymmetric β-functionalization of unsaturated carbonyl compounds. In this review, recent advances on the catalytic asymmetric radical functionalization of imines and iminium intermediates are summarized. 1 Introduction 2 Enantioselective Radical Functionalization of Imines 2.1 Asymmetric Reduction 2.2 Asymmetric Cyclization 2.3 Asymmetric Addition 2.4 Asymmetric Radical–Radical Coupling 3 Enantioselective Radical Functionalization of Iminium Ions 3.1 Asymmetric Radical Alkylation 3.2 Asymmetric Radical Acylation 4 Conclusion