穿孔道
癫痫
海马结构
刺激
癫痫发生
近颞叶癫痫
神经科学
脑深部刺激
光遗传学
海马体
海马硬化
颞叶
医学
全身性癫痫
心理学
内科学
齿状回
疾病
帕金森病
作者
Enya Paschen,Claudio Elgueta,Katharina Heining,Diego M. Vieira,Piret Kleis,Catarina Orcinha,Ute Häussler,Marlene Bartos,Ulrich Egert,Philipp Janz,Carola A. Haas
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2020-12-22
卷期号:9
被引量:40
摘要
Mesial temporal lobe epilepsy (MTLE) is the most common form of focal, pharmacoresistant epilepsy in adults and is often associated with hippocampal sclerosis. Here, we established the efficacy of optogenetic and electrical low-frequency stimulation (LFS) in interfering with seizure generation in a mouse model of MTLE. Specifically, we applied LFS in the sclerotic hippocampus to study the effects on spontaneous subclinical and evoked generalized seizures. We found that stimulation at 1 Hz for 1 hr resulted in an almost complete suppression of spontaneous seizures in both hippocampi. This seizure-suppressive action during daily stimulation remained stable over several weeks. Furthermore, LFS for 30 min before a pro-convulsive stimulus successfully prevented seizure generalization. Finally, acute slice experiments revealed a reduced efficacy of perforant path transmission onto granule cells upon LFS. Taken together, our results suggest that hippocampal LFS constitutes a promising approach for seizure control in MTLE.
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