[The processes of lipo-peroxidation and the system of antioxidant defense in women with sleep disorders in menopause: the ethnic aspect].

The purpose of study was to evaluate the system ofperoxidation of lipids as an antioxidant defense in women of peri-menopause period with sleep disorders. The sampling included 73 examined women of peri-menopause period of Russian (n=45) and Buryat (n=28) ethnic groups. All women were applied clinical anamnestic examination. The evaluation of sleep disorders was implemented using the Stanford Center for Sleep sciences and medicine questionnaire, the insomnia subjective severity evaluation test, questionnaires of quantitative estimate of risk of occurrence of syndrome of obstructive sleep apnea and the Epworth Sleepiness Scale. According the results of survey the ethnic groups were separated on main (with sleep disorders) and control (without sleep disorders) subgroups. The processes of lipoperoxidation and the system antioxidant defense are evaluated using spectrophotometric techniques. The survey established higher rate of occurrence of troubles with falling asleep and morning awakenings in female representatives of the Russian ethnic group. The total number on the Epworth Sleepiness Scale in the Russian group amounted to 12.2±0.42 and in the Buryat group - 10.01±1.29. The study of processes of lipoperoxidation in women of the Russian ethnic group established increasing of level of ketodienes and coupled trienes (p<0.05) in subgroup with sleep disorders as compared with control group. The sleep disorders in women of Buryat ethnic group are accompanied by higher levels of substrates of lipoperoxidation with coupled doubled bounds (p<0.05), diene conjugates (p<0.05), ketodienes and coupled trienes (p<0.05). The value of coefficient of oxidative stress in female patients of Russian ethnic group amounted to 2.2 and in women of Buryat ethnic group - 3.8. The study results both demonstrate development of oxidative stress in female patients with sleep disorders in peri-menopause period in Russian and Buryat ethnic groups and substantiate ethnic specificity ofprocesses of lipoperoxidation.