Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017–2018

扎那米韦 病毒学 神经氨酸酶 奥司他韦 神经氨酸酶抑制剂 病毒 甲型流感病毒 生物 医学 2019年冠状病毒病(COVID-19) 传染病(医学专业) 疾病 病理
作者
Emi Takashita,Rod S. Daniels,Seiichiro Fujisaki,Vicki Gregory,Larisa V. Gubareva,Weiijuan Huang,Aeron C. Hurt,Angie Lackenby,Ha Nguyen,Dmitriy Pereyaslov,Merryn Roe,Magdi Samaan,Kanta Subbarao,Herman Tse,Dayan Wang,Hui‐Ling Yen,Wenqing Zhang,Adam Meijer
出处
期刊:Antiviral Research [Elsevier BV]
卷期号:175: 104718-104718 被引量:105
标识
DOI:10.1016/j.antiviral.2020.104718
摘要

The global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012–13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for the treatment of influenza virus infection in Japan and the United States. For this annual report, the susceptibilities of influenza viruses to NAIs and baloxavir were analyzed. A total of 15409 viruses, collected by World Health Organization (WHO) recognized National Influenza Centers and other laboratories between May 2017 and May 2018, were assessed for phenotypic NAI susceptibility by five WHO Collaborating Centers (CCs). The 50% inhibitory concentration (IC50) was determined for oseltamivir, zanamivir, peramivir and laninamivir. Reduced inhibition (RI) or highly reduced inhibition (HRI) by one or more NAIs was exhibited by 0.8% of viruses tested (n = 122). The frequency of viruses with RI or HRI has remained low since this global analysis began (2012–13: 0.6%; 2013–14: 1.9%; 2014–15: 0.5%; 2015–16: 0.8%; 2016–17: 0.2%). PA gene sequence data, available from public databases (n = 13523), were screened for amino acid substitutions associated with reduced susceptibility to baloxavir (PA E23G/K/R, PA A36V, PA A37T, PA I38F/M/T/L, PA E119D, PA E199G): 11 (0.08%) viruses possessed such substitutions. Five of them were included in phenotypic baloxavir susceptibility analysis by two WHO CCs and IC50 values were determined. The PA variant viruses showed 6–17-fold reduced susceptibility to baloxavir. Overall, in the 2017–18 period the frequency of circulating influenza viruses with reduced susceptibility to NAIs or baloxavir was low, but continued monitoring is important.
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