生物相容性
材料科学
壳聚糖
复合数
多孔性
肿胀 的
复合材料
微观结构
抗压强度
化学工程
胶体
工程类
冶金
作者
Rui-Lian Ying,Huachun Wang,Ruixue Sun,Kezheng Chen
标识
DOI:10.1016/j.msec.2020.110689
摘要
Hydroxyapatite/chitosan (HAp/CS) composites have been widely studied and applied in tissue engineering fields due to their excellent biocompatibility and degradability. However, to improve the mechanical properties of CS, cross-linking agents are commonly added, which will seriously affect its biocompatibility and safety. In this study, the homogenously dispersed nano-hydroxyapatite (nHAp) colloidal solution was first synthesized using a co-precipitation method. The three-dimensional porous nano-hydroxyapatite/chitosan (nHAp/CS) composite scaffolds with different nHAp contents were then obtained through an environmentally friendly freeze-drying process without any cross-linking. The microstructure, porosity, phase composition, swelling ratio, mechanical properties, and biocompatibility of the nHAp/CS scaffolds were thoroughly investigated. The as-prepared nHAp/CS scaffolds exhibited a high porosity and excellent swelling performance. Compared with pure CS scaffolds, the nHAp/CS composite scaffolds not only showed higher compressive modulus but also exhibited better biocompatibility. This study provides a simple and environmentally friendly technique to construct three-dimensional porous nHAp/CS composite scaffolds, which demonstrate promising potential by being a scaffold material for bone tissue engineering.
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