Recent Research Progress in and Perspectives of Mesoionic Insecticides: Nicotinic Acetylcholine Receptor Inhibitors

Triflumezopyrim exemplifies a new class of mesoionic insecticides and has attracted increasing attention as a result of its unique structure, high level of insecticidal activity, new mechanisms of action, low toxicity toward non-target organisms, and environmental friendliness. It inhibits the nicotinic acetylcholine receptor and has high potency against sucking pests, including the brown planthopper (Nilaparvata lugens), which has developed serious resistance to conventional neonicotinoids and low cross-resistance to some newly developed neonicotinoids. This review focuses on the discovery, synthesis, structure–activity relationships, and mechanism of action of mesoionic insecticides. Finally, potential directions for the development of mesoionic insecticides are discussed.