材料科学
血栓
血栓形成
纳米技术
医学
生物医学工程
内科学
心脏病学
作者
Junchao Xu,Yinlong Zhang,Jiaqi Xu,Guangna Liu,Chunzhi Di,Xiao Zhao,Xiang Li,Yao Li,Ningbo Pang,Chengzhi Yang,Yanyi Li,Bozhao Li,Zefang Lu,Meifang Wang,Kesheng Dai,Rong Yan,Suping Li,Guangjun Nie
标识
DOI:10.1002/adma.201905145
摘要
Rapid cut-off of blood supply in diseases involving thrombosis is a major cause of morbidity and mortality worldwide. However, the current thrombolysis strategies offer limited results due to the therapeutics' short half-lives, low targeting ability, and unexpected bleeding complications. Inspired by the innate roles of platelets in hemostasis and pathological thrombus, platelet membrane-camouflaged polymeric nanoparticles (nanoplatelets) are developed for targeting delivery of the thrombolytic drug, recombinant tissue plasminogen activator (rt-PA), to local thrombus sites. The tailor-designed nanoplatelets efficiently accumulate at the thrombi in pulmonary embolism and mesenteric arterial thrombosis model mice, eliciting a significantly enhanced thrombolysis activity compared to free rt-PA. In addition, the nanoplatelets exhibit improved therapeutic efficacy over free rt-PA in an ischemic stroke model. Analysis of in vivo coagulation indicators suggests the nanoplatelets might possess a low risk of bleeding complications. The hybrid biomimetic nanoplatelets described offer a promising solution to improve the efficacy and reduce the bleeding risk of thrombolytic therapy in a broad spectrum of thrombosis diseases.
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