生物钟
DNA
转录因子
抄写(语言学)
体外
细胞生物学
化学
计算生物学
昼夜节律
生物物理学
生物
分子生物学
生物化学
基因
神经科学
语言学
哲学
作者
Yusuke Hosoya,Wataru Nojo,Isao Kii,Takanori Suzuki,Masahito Imanishi,Junko Ohkanda
摘要
Essential components of the human circadian clock, BMAL1 and CLOCK, which are intrinsically disordered transcription factors, were expressed and subjected to a fluorescent in vitro binding assay using an E-box DNA fragment. Screening of a chemical library identified 5,8-quinoxalinedione (1), which was found to inhibit binding of the heterodimer BMAL1/CLOCK to E-box at low micromolar concentrations.
科研通智能强力驱动
Strongly Powered by AbleSci AI