微泡
心力衰竭
小RNA
外体
医学
生物信息学
诊断生物标志物
内科学
生物
诊断准确性
基因
遗传学
作者
Rui‐De Xue,Weiping Tan,Yuzhong Wu,Bin Dong,Zengshuo Xie,Peisen Huang,Jiangui He,Yugang Dong,Chen Liu
标识
DOI:10.3389/fcvm.2020.592412
摘要
Heart failure is the terminal outcome of the majority of cardiovascular diseases, which lacks specific diagnostic biomarkers and therapeutic targets. It contributes to most of cardiovascular hospitalizations and death despite of the current therapy. Therefore, it is important to explore potential molecules improving the diagnosis and treatment of heart failure. MicroRNAs (miRNAs) are small non-coding RNAs that have been reported to be involved in regulating processes of heart failure. After the discovery of miRNAs in exosomes, the subcellular distribution analysis of miRNAs is raising researchers' attention. Growing evidence demonstrates that exosomal miRNAs may be promising diagnostic and therapeutic molecules for heart failure. This review summarizes the role of exosomal miRNAs in heart failure in the prospect of molecular and clinical researches.
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