DNA甲基化
表观遗传学
生物
甲基化
CpG站点
癌症研究
差异甲基化区
分子生物学
基因表达
遗传学
基因
作者
Gabriela Hernandez‐Meza,Johann von Felden,Edgar Gonzalez‐Kozlova,Teresa García‐Lezana,Judit Peix,Anna Portela,Amanda J. Craig,Sergi Sayols,Myron Schwartz,Bojan Losic,Vincenzo Mazzaferro,Manel Esteller,Josep M. Llovet,Augusto Villanueva
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2020-11-25
卷期号:74 (1): 183-199
被引量:112
摘要
Genome-wide DNA-methylation profiles accurately discriminate the different histological stages of human hepatocarcinogenesis. We report on epigenetic gatekeepers in the transition between dysplastic nodules and eHCC. DNA-methylation changes in cirrhotic tissue correlate with clinical outcomes.
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