材料科学
自愈水凝胶
软骨
聚合物
再生(生物学)
生物材料
复合材料
纳米技术
高分子化学
解剖
医学
生物
细胞生物学
作者
Wenxu Sun,Bin Xue,Ying Li,Meng Qin,Junyi Wu,Ke Lü,Junhua Wu,Yi Cao,Qing Jiang,Wei Wang
标识
DOI:10.1002/adfm.201603512
摘要
Mechanical properties of hydrogels are critical for their applications as articular cartilage regeneration scaffolds, because they provide not only the mechanical support, but also the mechanical cues essential to maintain the phenotype of cartilage‐forming cells. Inspired by the microscopic architecture of natural cartilage, here the engineering of a novel double‐network hydrogel with interconnected polymer‐supramolecular polymer double‐network (PS‐DN gel) for cartilage regeneration is reported. The polymer network is made of polyacrylamide and the supramolecular polymer network comprises of a kind of self‐assembled peptide fibers. Upon mechanical loading, the peptide fibers serve as sacrificial bonds to efficiently dissipate energy. They can quickly reform when mechanical load is released thanks to the fast and accurate peptide self‐assembly. These entail the PS‐DN gel of high mechanical strength of ≈0.32–0.57 MPa, fracture energy of ≈300–2670 J m −2 , compressibility of ≈66%–90%, and fast recovery in seconds. The gel also shows significant energy dissipation, strain stiffening, and stress relaxation behaviors similar to articular cartilage. Moreover, the mechanical properties of the PS‐DN gel can be tailored by adjusting the chemical components of the gel. Therefore, this novel biomaterial represents a promising candidate for the regeneration of cartilage and other load bearing tissues.
科研通智能强力驱动
Strongly Powered by AbleSci AI