化学
催化作用
反应条件
组合化学
自由基环化
三环
有机化学
作者
Arvind K. Yadav,Lal Dhar S. Yadav
标识
DOI:10.1016/j.tetlet.2016.12.077
摘要
An efficient [4+2] cyclization of N-methylanilines with maleimides to afford tetrahydroquinolines using N-hydroxyphthalimide as a metal-free and cheap organophotoredox catalyst is reported. The protocol involves C(sp3)H activation of N-methylanilines for the formation of α-amino radical without an oxidant at room temperature. The present method describes an easy preparation of tricyclic heterocycles in good to excellent yields under mild reaction conditions.
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