算盘(建筑)
蛋白质设计
计算机科学
功能(生物学)
序列(生物学)
氨基酸残基
氨基酸
算法
蛋白质结构
肽序列
化学
生物化学
生物
遗传学
历史
基因
考古
作者
Peng Xiong,Quan Chen,Haiyan Liu
出处
期刊:Methods in molecular biology
日期:2016-12-03
卷期号:: 217-226
被引量:13
标识
DOI:10.1007/978-1-4939-6637-0_10
摘要
An important objective of computational protein design is to identify amino acid sequences that stably fold into a given backbone structure. A general approach to this problem is to minimize an energy function in the sequence space. We have previously reported a method to derive statistical energies for fixed-backbone protein design and showed that it led to de novo proteins that fold as expected. Here, we present the usage of the program that implements this method, which we now name as ABACUS (A Backbone-based Amino aCid Usage Survey).
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