Biodistribution and excretion of colloidal gold nanoparticles after intravenous injection: Effects of particle size

体内分布 胶体金 尿 化学 排泄 粒径 药物输送 放射化学 药理学 纳米颗粒 纳米技术 材料科学 医学 体外 生物化学 物理化学
作者
Issei Takeuchi,Sho Nobata,Naoto Oiri,Keishiro Tomoda,Kimiko Makino
出处
期刊:Bio-medical Materials and Engineering [IOS Press]
卷期号:28 (3): 315-323 被引量:50
标识
DOI:10.3233/bme-171677
摘要

Background:Inorganic gold nanoparticles (NPs) have a huge potential in targeted drug delivery. Simple preparation and surface modification procedure with their special physicochemical properties of gold NPs attract their use such as tumor targeting and the detection of cancerous cell. Objective:Var ious studies were reported, however, details of biodistribution profile of gold NPs were not enough evaluated. We have studied biodistribution profile of gold NPs having various particle sizes (20, 50 and 100 nm). Methods:Gold concentrations in brain, heart, lungs, liver, stomach, pancreas, spleen, kidneys, blood, urine, and feces were measured at 5 minutes, 0.25, 0.5, 1, 2, 3, 6, 12, 18 and 24 hours after administration of gold NPs using inductively coupled plasma atomic emission spectrometry. Results:In lungs and brain, especially 20-nm gold NPs were accumulated after 2-3 hours of dose administration, and they were kept for 24 hours, whereas they showed relatively low accumulation in heart, stomach and pancreas. After 12 hours, 3.3–14.4% of the injected gold were observed in fecal matter and urine. Conclusions:From this study, the application of gold NPs for targeted delivery to lungs and brain and the excretion route of the gold NPs from the body were suggested
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
muming完成签到,获得积分20
1秒前
sanlunainiu发布了新的文献求助10
1秒前
林博研完成签到,获得积分20
1秒前
FashionBoy应助风趣的灵枫采纳,获得10
2秒前
3秒前
yihuiqing发布了新的文献求助10
4秒前
likke发布了新的文献求助10
4秒前
嗝嗝发布了新的文献求助10
4秒前
小兔狸花昕完成签到,获得积分20
5秒前
IRer79完成签到,获得积分10
7秒前
彭于晏应助noah采纳,获得10
7秒前
青年才俊发布了新的文献求助10
7秒前
zhu发布了新的文献求助10
8秒前
波波蛋完成签到,获得积分10
8秒前
9秒前
10秒前
11秒前
maguodrgon发布了新的文献求助10
14秒前
科研通AI5应助shell采纳,获得80
14秒前
波波蛋发布了新的文献求助10
14秒前
15秒前
九鹤完成签到,获得积分10
15秒前
jsy完成签到,获得积分10
15秒前
量子星尘发布了新的文献求助10
16秒前
旷野发布了新的文献求助10
16秒前
16秒前
Owen应助浮云521采纳,获得10
16秒前
浮游应助muming采纳,获得10
16秒前
酷炫的凤妖完成签到 ,获得积分10
17秒前
18秒前
18秒前
20秒前
20秒前
20秒前
21秒前
22秒前
浮游应助勤劳的莆采纳,获得10
22秒前
23秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
By R. Scott Kretchmar - Practical Philosophy of Sport and Physical Activity - 2nd (second) Edition: 2nd (second) Edition 666
Energy-Size Reduction Relationships In Comminution 500
Principles Of Comminution, I-Size Distribution And Surface Calculations 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4941339
求助须知:如何正确求助?哪些是违规求助? 4207390
关于积分的说明 13077624
捐赠科研通 3986257
什么是DOI,文献DOI怎么找? 2182529
邀请新用户注册赠送积分活动 1198125
关于科研通互助平台的介绍 1110387