Do -synuclein aggregates in autonomic plexuses predate Lewy body disorders?: A cohort study

医学 纯自主神经功能衰竭 瓦萨尔瓦机动 队列 人口 路易体 痴呆 路易氏体型失智症 自主神经系统 内科学 血压 帕金森病 病理 疾病 直立生命体征 心率 环境卫生
作者
Adolfo Mínguez‐Castellanos,Claudio Chamorro,Francisco Escamilla-Sevilla,A Ortega-Moreno,Angelita Rebollo,Manuel Gómez-Río,Alejandro Concha,David G. Muñoz
出处
期刊:Neurology [Lippincott Williams & Wilkins]
卷期号:68 (23): 2012-2018 被引量:177
标识
DOI:10.1212/01.wnl.0000264429.59379.d9
摘要

To determine the prevalence of alpha-synuclein (AS) aggregates in abdominopelvic autonomic plexuses in the general population and to evaluate the relationship between this finding and the subsequent development of neurologic dysfunction.First, surgical specimens from 100 patients (ages 44 to 84) undergoing a wide resection of an abdominopelvic organ were examined by anti-AS immunostaining. Second, 16 patients (6 AS+ and 10 randomly selected AS-) participated in yearly double-blinded neurologic assessments.AS aggregates were found in autonomic plexuses in 9% of the whole sample (95% CI 3.4 to 14.6%) but were more common in vesicoprostatic (26%) than in digestive tract (4%) specimens. At 16 months after the biopsy, no prevalent cases of Parkinson disease, dementia, or autonomic failure were diagnosed among participants. One AS+ patient had previously been diagnosed with REM sleep behavior disorder. Seven of 10 control subjects but none of the 6 AS+ patients had a diagnosis of hypertension (p = 0.01). During phase IV of Valsalva maneuver, AS+ group exhibited a longer blood pressure recovery time (p = 0.03), with one patient showing absence of blood pressure overshoot. Cardiac [(123)I]metaiodobenzylguanidine uptake was reduced in the AS+ group (p = 0.03). Striatal [(123)I]ioflupane uptake was abnormally low in only one AS+ patient. At 30 months after the biopsy, lower cardiac and striatal uptake values tended to correlate with higher Unified Parkinson's Disease Rating Scale III scores (p = 0.07).The common presence of alpha-synuclein aggregates in peripheral autonomic neurons may represent an early presymptomatic phase in the development of Lewy body disorders.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
今后应助连冷安采纳,获得10
1秒前
2秒前
领导范儿应助Haha采纳,获得10
2秒前
2秒前
天天快乐应助调皮傲旋采纳,获得10
4秒前
S8发布了新的文献求助10
4秒前
黄金城发布了新的文献求助10
5秒前
浮游应助Jimmy Ko采纳,获得10
6秒前
6秒前
量子星尘发布了新的文献求助10
6秒前
6秒前
7秒前
白熊发布了新的文献求助30
7秒前
8秒前
8秒前
10秒前
zhu发布了新的文献求助10
11秒前
11秒前
独特听芹完成签到,获得积分10
13秒前
zz完成签到,获得积分10
13秒前
14秒前
晚风完成签到,获得积分10
15秒前
jwj发布了新的文献求助10
16秒前
16秒前
白熊完成签到 ,获得积分10
16秒前
17秒前
李健应助北齐冲浪的鱼采纳,获得10
18秒前
18秒前
王一鸣发布了新的文献求助10
19秒前
ikutovaya完成签到,获得积分10
19秒前
19秒前
奋斗的妙松完成签到,获得积分10
20秒前
老实莫言完成签到,获得积分10
20秒前
21秒前
量子星尘发布了新的文献求助150
21秒前
wop111应助morph采纳,获得20
21秒前
追寻的冬寒完成签到 ,获得积分10
22秒前
23秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
NMR in Plants and Soils: New Developments in Time-domain NMR and Imaging 600
Electrochemistry: Volume 17 600
Physical Chemistry: How Chemistry Works 500
SOLUTIONS Adhesive restoration techniques restorative and integrated surgical procedures 500
Energy-Size Reduction Relationships In Comminution 500
Principles Of Comminution, I-Size Distribution And Surface Calculations 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4950711
求助须知:如何正确求助?哪些是违规求助? 4213460
关于积分的说明 13104286
捐赠科研通 3995337
什么是DOI,文献DOI怎么找? 2186837
邀请新用户注册赠送积分活动 1202090
关于科研通互助平台的介绍 1115359