淋巴毒素
生物
免疫系统
淋巴毒素β受体
淋巴系统
免疫学
主要组织相容性复合体
高内皮静脉
T细胞
黑色素瘤
抗原
淋巴毒素α
淋巴因子
融合蛋白
癌症研究
重组DNA
基因
生物化学
作者
David Schrama,Per thor Straten,Wolfgang Fischer,Alexander D. McLellan,Eva‐Bettina Bröcker,Ralph A. Reisfeld,Eva‐Bettina Bröcker
出处
期刊:Immunity
[Elsevier]
日期:2001-02-01
卷期号:14 (2): 111-121
被引量:167
标识
DOI:10.1016/s1074-7613(01)00094-2
摘要
A recombinant antibody-lymphotoxin-α fusion protein induced an adaptive immune response protecting mice from melanoma. Importantly, this fusion protein elicited the formation of a lymphoid-like tissue in the tumor microenvironment containing L-selectin+ T cells and MHC class II+ antigen-presenting cells, as well as B and T cell aggregates. Furthermore, PNAd+/TCA4+ high endothelial venules were observed within the tumor, suggesting entry channels for naive T cell infiltrates. Over the course of therapy, a marked clonal expansion of certain TCR specificities occurred among tumor-infiltrating lymphocytes that displayed reactivity against melanoma cells and the TRP-2180–188 peptide. Consequently, naive T cells may have been recruited to as well as primed and expanded in the lymphoid-like tissue induced by the lymphotoxin-α fusion protein at the tumor site.
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