尼古丁
NMDA受体
烟碱乙酰胆碱受体
海马结构
烟碱激动剂
乙酰胆碱受体
化学
乙酰胆碱
药理学
海马体
受体
甲基枸杞碱
α-4β-2烟碱受体
神经科学
内分泌学
内科学
心理学
医学
生物化学
作者
Namık Delibaş,Duygu Kumbul Doğuç,Recep Sütçü,Erol Eroğlu,Osman Gökalp
标识
DOI:10.1080/00207450590914437
摘要
Nicotinic acetylcholine (nAChR) and N-methyl-D-aspartate receptors (NMDARs) play critical roles in memory function. This study administered chronic nicotine to determine the alterations of N-methyl-D-aspartate receptor subunit 2A and 2B (NR2A, NR2B) and the alterations of alpha7nAChR receptor. It was determined that the effectivity of nicotine and the data support that nicotine increases hippocampal NR2A and B expression. Additionally, the role of nicotine in the cognitive improvement was not supported by the antioxidative mechanisms or the authors observed no effect of nicotine on lipid peroxidation at the hippocampus.
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