Prevalence of Neurofibromatosis 1 in German Children at Elementary School Enrollment

Objective: To determine the prevalence of neurofibromatosis 1 (NF1) among 6-year-old children in Germany.Setting and Patients: A total of 152 819 children aged 6 years in 6 German states were screened for NF1 during routine medical examinations at elementary school enrollment in cooperation with local health departments in 2000 and 2001.Main Outcome Measure: The prevalence of NF1 among 6-year-old German children was estimated to be 1:2996 (95% confidence interval, 1:2260 to 1:3984).Results: Fifty-one NF1 cases were identified and confirmed by evaluation by appropriate medical specialists.