Cationic Three-component Coupling Involving an Optically Active Enamine Derivative. From Time Integration to Space Integration of Reactions

Abstract Three-component coupling of an N-acyliminium cation pool, an optically active 2-t-butyloxazole derivative, and a carbon nucleophile such as allyltrimethylsilane was effectively achieved by a rapid one-pot method at −78 °C and a flow microreactor method at 0 °C.