Mixed treatment comparison of dronedarone, amiodarone, sotalol, flecainide, and propafenone, for the management of atrial fibrillation

医学 胺碘酮 决奈达隆 普罗帕酮 索他洛尔 弗莱卡奈德 心房颤动 促心律失常 心脏病学 心房扑动 内科学 麻醉 不利影响 安慰剂 抗心律失常药 窦性心律 心脏病 替代医学 病理
作者
Nick Freemantle,Carmelo Lafuente-Lafuente,Stephen Mitchell,Laurent Eckert,Matthew R. Reynolds
出处
期刊:Europace [Oxford University Press]
卷期号:13 (3): 329-345 被引量:176
标识
DOI:10.1093/europace/euq450
摘要

Mixed treatment comparisons (MTC) were performed to assess the relative efficacy and tolerability of the main anti-arrhythmic drugs used for the treatment of atrial fibrillation (AF)/flutter.Electronic databases were systematically searched to identify randomized controlled trials (RCTs) examining amiodarone, dronedarone, flecainide, propafenone, sotalol, or placebo for the treatment of AF. Thirty-nine RCTs met inclusion criteria and were combined using MTC models to provide direct and indirect comparisons in a single analysis. Results are presented vs. placebo. Amiodarone had the largest effect in reducing AF recurrence (OR 0.22, 95% CI 0.16-0.29). Amiodarone was associated with the highest rate of patients experiencing at least one serious adverse event (OR 2.41, 95% CI 0.96-6.06) and treatment withdrawals due to adverse events (OR 2.91, 95% CI 1.66-5.11). Dronedarone was associated with the lowest rate of proarrhythmic events including bradycardia (OR 1.45, 95% CI 1.02-2.08). Dronedarone significantly reduced the risk of stroke (OR 0.69, 95% CI 0.57-0.84). Trends towards increased mortality for sotalol (OR 3.44, 95% CI 1.02-11.59) and amiodarone (OR 2.17, 95% CI 0.63-7.51) were found, which were stronger when small studies randomizing <100 subjects per group were excluded.Amiodarone has been demonstrated to be the most effective drug in maintaining sinus rhythm. Differences in outcomes between the anti-antiarrhythmic drugs were reported, with sotalol and possibly amiodarone increasing mortality and dronedarone possibly decreasing the incidence of serious adverse events and proarrhythmia.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丁仪完成签到,获得积分10
1秒前
1秒前
NexusExplorer应助大力的水风采纳,获得10
2秒前
2秒前
2秒前
中宝发布了新的文献求助10
2秒前
2秒前
Ava应助Ing采纳,获得10
2秒前
2秒前
3秒前
樱悼柳雪发布了新的文献求助10
3秒前
4秒前
stefan发布了新的文献求助10
4秒前
大傻春发布了新的文献求助10
4秒前
852应助亮亮采纳,获得10
4秒前
5秒前
5秒前
fff发布了新的文献求助10
5秒前
庞鲂发布了新的文献求助30
5秒前
勤劳的老九应助兔年吉祥采纳,获得10
6秒前
量子星尘发布了新的文献求助10
6秒前
6秒前
sofar完成签到 ,获得积分10
6秒前
6秒前
7秒前
小马甲应助sup采纳,获得10
7秒前
yyyyyyy111发布了新的文献求助10
7秒前
现代的小馒头完成签到,获得积分10
7秒前
wxy发布了新的文献求助10
7秒前
万能图书馆应助小地蛋采纳,获得10
7秒前
无花果应助豆豆采纳,获得10
7秒前
8秒前
您的帮助将会点亮世界完成签到,获得积分10
8秒前
9秒前
yar应助lcy采纳,获得10
9秒前
要减肥的香芦完成签到,获得积分10
10秒前
hunbaekkkkk完成签到 ,获得积分10
11秒前
qiu完成签到,获得积分10
11秒前
十一发布了新的文献求助10
12秒前
12秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974844
求助须知:如何正确求助?哪些是违规求助? 3519270
关于积分的说明 11197844
捐赠科研通 3255496
什么是DOI,文献DOI怎么找? 1797791
邀请新用户注册赠送积分活动 877187
科研通“疑难数据库(出版商)”最低求助积分说明 806202