医学
冲程(发动机)
寄主(生物学)
中枢神经系统
神经系统
肠-脑轴
神经科学
病理
免疫学
内科学
肠道菌群
生物
精神科
遗传学
机械工程
工程类
作者
Alexander Swidsinski,Vera Loening-Baucke,Monika Krüger,Steffen Kirsch
出处
期刊:Intestinal Research
[Korean Association for the Study of Intestinal Diseases (KAMJE)]
日期:2012-01-01
卷期号:10 (4): 332-332
被引量:22
标识
DOI:10.5217/ir.2012.10.4.332
摘要
Background/Aims: Stroke is accompanied by septic complications due to quickly changing polymicrobials of unclear origin. This study was aimed to find the source of stroke-associated-infections. Methods: We investigated the biostructure of the colonic microbiota in patients hospitalized in two stroke units using fluorescence in situ hybridization in order to find the source of stroke-associated-infections. Non-stroke subjects and animals were used as controls. Results: Typical for stroke was a leukocyte migration into the mucus between day 1-3, in numbers that are otherwise characteristic for active ulcerative colitis (CAI ≥6); subsequent abrupt “decontamination” of the main fermentative Roseburia, Bacteroides and Faecalibacterium prausnitzii groups and disappearance of leukocytes in the stool; arrest of bacterial fermentation between day 3 to 7 in extents exceeding the effects of any presently know antibiotics. Then resetting in which Enterobacteriaceae, Bifidobacteriaceae and Clostridium difficile temporarily outnumber Bacteroides, Roseburia and Faecalibacterium prausnitzii, and after that decline with normalization of these bacteria to initial values. Conclusions: The colon is a bioreactor containing many potential pathogens. The mucus barrier shields the host from bacteria. The events following stroke stress the pivotal role of the brain in maintaining this shield and indicate an existence of emergency brakes that temporary terminate the biofermentation. (Intest Res 2012;10:332-342)
科研通智能强力驱动
Strongly Powered by AbleSci AI