高氨血症
乙酰唑胺
碱中毒
医学
内科学
尿素循环
内分泌学
化学
酸中毒
生物化学
氨基酸
精氨酸
作者
Carmen M.A. Bles,J.G. van der Hoeven,Cornelia Hoedemaekers
出处
期刊:Netherlands Journal of Critical Care
日期:2014-01-01
卷期号:18: 25-27
被引量:1
摘要
Nonhepatic hyperammonaemia is a rare disorder in the ICU. We describe a patient who developed hyperammonaemia after the administration of acetazolamide. Acetazolamide is a frequently used drug in the ICU for the correction of metabolic alkalosis. Acetazolamide-associated hyperammonemia may develop due to interference with the breakdown of ammonia through the urea cycle and through inhibition of the renal excretion of ammonia. Possible treatment options for hyperammonemia have been reviewed. Although the frequency of acetazolamide-induced hyperammonemia is unknown in ICU patients, it is a condition that must be considered when patients treated with acetazolamide show unexplained changes in consciousness.
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