抗细菌
生药学
预酸化
细胞毒性T细胞
传统医学
立体化学
化学
生物活性
抗菌剂
生物
微生物学
体外
医学
生物化学
肺结核
结核分枝杆菌
抗生素
病理
酶
作者
Somyote Sutthivaiyakit,Oracha Thongnak,Thitima Lhinhatrakool,Orapan Yodchun,Ratree Srimark,Prisana Dowtaisong,Mayuree Chuankamnerdkarn
摘要
Eight new prenylated flavonoids, khonklonginols A−H (1−8), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1−8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
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