Structure–function relationships in nuclear receptors: the facts

In their Opinion article, Rastinejad et al. [ 1 Rastinejad F. et al. Nuclear receptor full-length architectures: confronting myth and illusion with high resolution. Trends Biochem. Sci. 2015; 40: 16-24 Abstract Full Text Full Text PDF PubMed Scopus (52) Google Scholar ] made a comparative analysis between the structural results on full-length receptors (NRs) in solution and those resulting from three crystal structures. The provocative aspects of many statements and more importantly the incorrect assertions and the illusions that can be generated by the paper have prompted us to present the facts. For a good unbiased review with another perspective see [ 2 Helsen C. Claessens F. Looking at nuclear receptors from a new angle. Mol. Cell. Endocrinol. 2013; 382: 97-106 Crossref PubMed Scopus (91) Google Scholar ].