神经生长因子
医学
神经瘤
机制(生物学)
原肌球蛋白受体激酶A
炎症
内科学
外科
受体
认识论
哲学
作者
Duncan Atherton,O. Taherzadeh,P. Facer,David Elliot,Praveen Anand
出处
期刊:The journal of hand surgery
[SAGE]
日期:2006-12-01
卷期号:31 (6): 652-656
被引量:49
标识
DOI:10.1016/j.jhsb.2006.06.009
摘要
Painful neuromas have been successfully treated by surgical procedures including relocation to muscle, but the underlying molecular mechanism remains unclear. Nerve growth factor (NGF) is secreted by tissues and promotes the expression of ion channels and neuropeptides in sensory neurons involved in pain transmission. We hypothesised that excess of NGF may lead to pain in neuromas and that the efficacy of surgical relocation results from deprivation of NGF, i.e. translocation from NGF-rich regions, particularly sub-cutaneous structures associated with injury or inflammation, to NGF-poor structures such as muscle or bone. Using immunohistological methods with primary antibodies to rhNGF, we report that NGF levels were elevated in 13 painful neuromas in comparison with six control nerves. However, in four painful neuromata re-located into muscle with pain relief, the NGF level was similar to that of controls. NGF levels suggest an explanation for the development of painful neuromas and the efficacy of relocation.
科研通智能强力驱动
Strongly Powered by AbleSci AI