核蛋白
狂犬病病毒
病毒学
生物
抄写(语言学)
病毒
核糖核酸
病毒复制
RNA依赖性RNA聚合酶
水泡性口炎病毒
RNA聚合酶
聚合酶
RNA病毒
狂犬病
遗传学
基因
哲学
语言学
作者
Aurélie Albertini,Guy Schoehn,Winfríed Weissenhorn,Florence Baudin
标识
DOI:10.1007/s00018-007-7298-1
摘要
Rabies virus is a negative-strand RNA virus. Its RNA genome is condensed by the viral nucleoprotein (N), and it is this N-RNA complex that is the template for transcription and replication by the viral RNA-dependent RNA polymerase complex. Here we discuss structural and functional aspects of viral transcription and replication based on the atomic structure of a recombinant rabies virus N-RNA complex. We situate available biochemical data on N-RNA interactions with viral and cellular factors in the structural framework with regard to their implications for transcription and replication. Finally, we compare the structure of the rabies virus nucleoprotein with the structures of the nucleoproteins of vesicular stomatitis virus, Borna disease virus and influenza virus, highlighting potential similarities between these virus families.
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