Predictive factors of survival in patients with borderline resectable pancreatic cancer who received neoadjuvant therapy

医学 内科学 胃肠病学 多元分析 纳特 胰腺癌 新辅助治疗 回顾性队列研究 肿瘤科 癌症 计算机网络 计算机科学 乳腺癌
作者
Koji Tezuka,Yukiyasu Okamura,Teiichi Sugiura,Takaaki Ito,Yusuke Yamamoto,Ryo Ashida,Katsuhisa Ohgi,Shimpei Otsuka,Akiko Todaka,Akira Fukutomi,Katsuhiko Uesaka
出处
期刊:Pancreatology [Elsevier BV]
卷期号:21 (8): 1451-1459 被引量:4
标识
DOI:10.1016/j.pan.2021.08.009
摘要

This study aimed to develop the prognostic score (PS) based on clinical factors to stratify the prognosis in borderline resectable pancreatic cancer (BRPC) patients treated with neoadjuvant therapy (NAT).This retrospective study included 57 BRPC patients who received NAT between April 2012 and December 2017. A score was assigned to each prognostic factor available before and after NAT, according to their β coefficients.Multivariate analysis identified the following six prognostic factors, and scores were assigned as follows: being a familial PC patient (HR 4.98, p = 0.029), post-NAT CA19-9 ≥37 U/ml (HR 3.08, p = 0.020), reduction rate of CA19-9 <70% (HR 3.71, p = 0.008), pre-NAT neutrophil-to-lymphocyte ratio ≥2.8 (HR 4.32, p = 0.003), and non-resection (HR 3.98, p = 0.009) were scored as 1; and post-NAT albumin-to-globulin ratio <1.33 (HR 8.31, p < 0.001) was scored as 2. The PS was calculated by summing the scores assigned to each prognostic factor. Patients were then classified into three risk groups (low- [0-1 points], moderate- [2-3 points], and high-risk [4-6 points] groups). Median overall survival in the low-, moderate-, and high-risk groups were not reached, 37.5 months, and 11.8 months, respectively, and there were significant differences in survival among the three groups (p < 0.01 in each group).This study showed that the PS may be useful for predicting the prognosis of BRPC patients treated with NAT.
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