Dose Adjustment Associated Complications of Bone Morphogenetic Protein: A Longitudinal Assessment

医学 关节融合术 外科 脊柱融合术 腰椎 骨形态发生蛋白 颈椎前路椎间盘切除融合术 并发症 颈椎 生物化学 基因 病理 化学 替代医学
作者
Frank De Stefano,Turki Elarjani,Joshua D. Burks,Stephen V. Burks,Allan D. Levi
出处
期刊:World Neurosurgery [Elsevier BV]
卷期号:156: e64-e71 被引量:3
标识
DOI:10.1016/j.wneu.2021.08.142
摘要

Bone morphogenetic protein (BMP) is a growth factor that aids in osteoinduction and promotes bone fusion. There is a lack of literature regarding recombinant human BMP-2 (rhBMP-2) dosage in different spine surgeries. This study aims to investigate the trends in rhBMP-2 dosage and the associated complications in spinal arthrodesis.A retrospective study was conducted investigating spinal arthrodesis using rhBMP-2. Variables including age, procedure type, rhBMP-2 size, complications, and postoperative imaging were collected. Cases were grouped into the following surgical procedures: anterior lumbar interbody fusion/extreme lateral interbody fusion (ALIF/XLIF), posterior lumbar interbody fusion/transforaminal lumbar interbody fusion (PLIF/TLIF), posterolateral fusion (PLF), anterior cervical discectomy and fusion (ACDF), and posterior cervical fusion (PCF).A total of 1209 patients who received rhBMP-2 from 2006 to 2020 were studied. Of these, 230 were categorized as ALIF/XLIF, 336 as PLIF/TLIF, 243 as PLF, 203 as ACDF, and 197 as PCF. PCF (P < 0.001), PLIF/TLIF (P < 0.001), and PLF (P < 0.001) demonstrated a significant decrease in the rhBMP-2 dose used per level, with major transitions seen in 2018, 2011, and 2013, respectively. In our sample, 129 complications following spinal arthrodesis were noted. A significant relation between rhBMP-2 size and complication rates (χ2= 73.73, P = 0.0029) was noted. rhBMP-2 dosage per level was a predictor of complication following spinal arthrodesis (odds ratio = 1.302 [1.05-1.55], P < 0.001).BMP is an effective compound in fusing adjacent spine segments. However, it carries some regional complications. We demonstrate a decreasing trend in the dose/vertebral level. A decrease rhBMP-2 dose per level correlated with a decrease in complication rates.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
糜轩完成签到,获得积分10
1秒前
独特大米完成签到,获得积分20
1秒前
红色鼻涕虫完成签到,获得积分20
2秒前
阿州发布了新的文献求助10
2秒前
2秒前
3秒前
3秒前
卡卡西应助一碗鱼采纳,获得20
3秒前
3秒前
4秒前
独特大米发布了新的文献求助20
6秒前
7秒前
8秒前
8秒前
8秒前
顾矜应助勤劳茗采纳,获得10
8秒前
9秒前
11完成签到,获得积分10
9秒前
11秒前
11秒前
xqing发布了新的文献求助30
12秒前
跳跃如豹发布了新的文献求助10
13秒前
13秒前
14秒前
KD_SWMU发布了新的文献求助10
14秒前
14秒前
15秒前
看太阳的均爷完成签到,获得积分10
15秒前
16秒前
大模型应助15832369693采纳,获得10
17秒前
刘无敌完成签到 ,获得积分10
17秒前
mof发布了新的文献求助10
17秒前
量子星尘发布了新的文献求助10
18秒前
19秒前
19秒前
mhlxxx发布了新的文献求助10
20秒前
21秒前
周帆完成签到,获得积分10
21秒前
yar应助Jason-1024采纳,获得10
22秒前
lwkk完成签到 ,获得积分10
24秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975543
求助须知:如何正确求助?哪些是违规求助? 3519971
关于积分的说明 11200248
捐赠科研通 3256311
什么是DOI,文献DOI怎么找? 1798213
邀请新用户注册赠送积分活动 877446
科研通“疑难数据库(出版商)”最低求助积分说明 806338