已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Cholinesterase is Associated With Prognosis and Response to Chemotherapy in Advanced Gastric Cancer

医学 内科学 化疗 单变量分析 生物标志物 多元分析 胃肠病学 癌症 逻辑回归 胆碱酯酶 无进展生存期 转移 肿瘤科 生物化学 化学
作者
Yanzhi Bi,Junling Zhang,Zeng Dan,Lili Chen,Wei Ye,Qin Yang,Yang Ling
出处
期刊:Pathology & Oncology Research [Springer Science+Business Media]
卷期号:27 被引量:10
标识
DOI:10.3389/pore.2021.580800
摘要

Background: Cholinesterase (CHE) is a routine serum biomarker in gastric cancer (GC). However, little research has been done on its clinical value in advanced GC. In addition, it is not clear whether it can be used as biomarker for the response and prognosis of advanced GC patients. Methods: Between Jan. 2013 and Dec. 2016, a total of 150 patients with advanced GC treated with first-line chemotherapy were admitted to Changzhou Tumor Hospital Affiliated to Soochow University. We retrospectively identified serum CHE level on the day before chemotherapy and at the end of chemotherapy and abstracted clinicopathologic features and treatment outcomes. Univariate and multivariate survival analyses were performed to assess the relationship between serum CHE levels and progression-free survival (PFS) and overall survival (OS). Results: A total of 150 advanced GC patients were included and divided into serum level ≥5,000 IU/L and serum level <5,000 IU/L. CHE level lower than 5,000 IU/L was associated with poorer PFS (HR, 1.60; 95% CI, 1.141–2.243; p = 0.006), poorer OS (HR, 1.76; 95% CI, 1.228–2.515; p = 0.002) and trend of poorer response (HR, 0.56; 95% CI, 0.272–1.129; p = 0.104). In univariate and multivariate logistic regression analysis, only liver metastasis and PS score were significantly associated with objective response ( p < 0.05). The medium PFS was 8.0 months in patients with post-treatment CHE increased vs. 3.8 months in patients with CHE decreased after chemotherapy (HR, 1.82; 95% CI 1.28–2.57; p = 0.0002). The medium OS was 13.1 months in patients with increased post-treatment CHE vs. 8.1 months in patients with decreased post-treatment CHE (HR, 1.87; 95% CI 1.29–2.71; p = 0.0002). Conclusion: Advanced GC with CHE levels below 5,000 IU/L was significantly associated with poor PFS and OS. The results suggested that CHE analysis before chemotherapy was a promising prognostic marker for advanced GC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
xiaofeiyan发布了新的文献求助20
刚刚
john发布了新的文献求助10
2秒前
2秒前
哆小咪完成签到 ,获得积分10
2秒前
554802336应助666采纳,获得30
2秒前
3秒前
tyjie完成签到 ,获得积分10
4秒前
5秒前
Jasper应助英俊的咖啡豆采纳,获得30
5秒前
6秒前
7秒前
AC赵先生发布了新的文献求助10
7秒前
8秒前
哈哈完成签到,获得积分20
9秒前
丁真先生完成签到,获得积分10
10秒前
10秒前
CodeCraft应助重要的如天采纳,获得10
10秒前
ohh发布了新的文献求助10
11秒前
暴躁的鸿发布了新的文献求助10
12秒前
14秒前
简约生活发布了新的文献求助10
14秒前
小小斌完成签到,获得积分10
15秒前
打打应助Friday采纳,获得10
16秒前
李健应助Master采纳,获得10
17秒前
19秒前
卡恩完成签到 ,获得积分10
19秒前
20秒前
Ava应助Jemma采纳,获得10
21秒前
22秒前
bc应助john采纳,获得20
23秒前
24秒前
24秒前
skyrmion发布了新的文献求助10
25秒前
26秒前
自信的九娘完成签到,获得积分10
27秒前
ohh完成签到,获得积分10
27秒前
27秒前
song发布了新的文献求助10
28秒前
ZJHYNL发布了新的文献求助30
29秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976455
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203728
捐赠科研通 3257156
什么是DOI,文献DOI怎么找? 1798618
邀请新用户注册赠送积分活动 877819
科研通“疑难数据库(出版商)”最低求助积分说明 806523