Insect odorant receptor-based biosensors: Current status and prospects

嗅觉系统 嗅觉 生物 嗅觉感受器 生物传感器 昆虫 计算生物学 神经科学 计算机科学 生态学 生物化学
作者
Jamal Ahmed Cheema,Colm Carraher,Natalie O. V. Plank,Jadranka Travaš‐Sejdić,Andrew V. Kralicek
出处
期刊:Biotechnology Advances [Elsevier BV]
卷期号:53: 107840-107840 被引量:25
标识
DOI:10.1016/j.biotechadv.2021.107840
摘要

Whilst the senses of vision and hearing have been successfully automated and miniaturized in portable formats (e.g. smart phone), this is yet to be achieved with the sense of smell. This is because the sensing challenge is not trivial as it involves navigating a chemosensory space comprising thousands of volatile organic compounds. Distinct aroma recognition is based on detecting unique combinations of volatile organic compounds. In natural olfactory systems this is accomplished by employing odorant receptors (ORs) with varying specificities, together with combinatorial neural coding mechanisms. Attempts to mimic the remarkable sensitivity and accuracy of natural olfactory systems has therefore been challenging. Current portable chemical sensors for odorant detection are neither sensitive nor selective, prompting research exploring artificial olfactory devices that use natural OR proteins for sensing. Much research activity to develop OR based biosensors has concentrated on mammalian ORs, however, insect ORs have not been explored as extensively. Insects possess an extraordinary sense of smell due to a repertoire of odorant receptors evolved to interpret olfactory cues vital to the insects' survival. The potential of insect ORs as sensing elements is only now being unlocked through recent research efforts to understand their structure, ligand binding mechanisms and development of odorant biosensors. Like their mammalian counterparts, there are many challenges with working with insect ORs. These include expression, purification and presentation of the insect OR in a stable display format compatible with an effective transduction methodology while maintaining OR structure and function. Despite these challenges, significant progress has been demonstrated in developing OR-based biosensors which exploit insect ORs in cells, lipid bilayers, liposomes and nanodisc formats. Ultrasensitive and highly selective detection of volatile organic compounds has been validated by coupling these insect OR display formats with transduction methodologies spanning optical (fluorescence) and electrical (field effect transistors, electrochemical impedance spectroscopy) techniques. This review summarizes the current status of insect OR based biosensors and their future outlook.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
maying0318发布了新的文献求助10
1秒前
宣以晴完成签到,获得积分10
1秒前
Nnn完成签到,获得积分10
2秒前
baby完成签到,获得积分10
5秒前
123完成签到,获得积分10
5秒前
6秒前
学术牛马完成签到,获得积分10
6秒前
sl发布了新的文献求助10
8秒前
完美的鹤完成签到,获得积分10
9秒前
hky完成签到,获得积分10
10秒前
TTTHANKS完成签到 ,获得积分10
11秒前
WW完成签到,获得积分10
11秒前
LL完成签到,获得积分10
12秒前
量子星尘发布了新的文献求助10
12秒前
小马的可爱老婆2完成签到,获得积分10
12秒前
缥缈纲完成签到,获得积分10
13秒前
TY完成签到 ,获得积分10
13秒前
迷路的小蚂蚁完成签到,获得积分10
14秒前
哈儿的跟班完成签到,获得积分10
14秒前
醉熏的鑫完成签到,获得积分20
15秒前
远_09完成签到 ,获得积分10
16秒前
网站技术人员完成签到,获得积分10
17秒前
eazin完成签到 ,获得积分10
18秒前
山野桃饼完成签到,获得积分10
18秒前
无私代芹完成签到,获得积分10
19秒前
画风湖湘卷完成签到,获得积分10
19秒前
段一帆完成签到,获得积分10
20秒前
结实的老虎完成签到,获得积分10
20秒前
20秒前
邓希静完成签到,获得积分10
21秒前
24秒前
25秒前
25秒前
27秒前
是冬天完成签到,获得积分10
28秒前
mengwensi完成签到,获得积分10
28秒前
单纯血茗发布了新的文献求助10
28秒前
胡大嘴先生完成签到,获得积分10
28秒前
林钟望完成签到,获得积分10
28秒前
碧蓝碧凡发布了新的文献求助10
29秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029