细菌
酶
生物
细菌外膜
抗生素
生物化学
蛋白酶
微生物学
信号肽酶
铜绿假单胞菌
信号肽
肽序列
大肠杆菌
遗传学
基因
作者
Lutz Vogeley,Toufic El Arnaout,Jonathan Bailey,Phillip J. Stansfeld,Coilín Boland,Martin Caffrey
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2016-02-19
卷期号:351 (6275): 876-880
被引量:121
标识
DOI:10.1126/science.aad3747
摘要
Insight into a bacterial membrane protease Lipoproteins have key functions in many bacteria. They are synthesized in a precursor form that requires processing by enzymes that are essential in many pathogenic bacteria but have no equivalent in humans, making them potential drug targets. LspA is a key membrane protein involved in lipoprotein maturation in the bacterium Pseudomonas aeruginosa . Vogeley et al. determined the crystal structure of LspA bound to the antibiotic globomycin. Their structure and mutagenesis studies reveal how LspA processes substrate lipoproteins and indicate that globomycin inhibits the enzyme by binding to the active site. These findings should be useful in the development of new antibiotics. Science , this issue p. 876
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