沸石咪唑盐骨架
咪唑酯
药物输送
生物相容性
材料科学
体内
纳米颗粒
纳米技术
阿霉素
纳米载体
化学
核化学
生物物理学
有机化学
金属有机骨架
医学
化疗
生物技术
吸附
生物
外科
冶金
作者
Mengni He,Jiajia Zhang,Jian Chen,Fangcai Zheng,Dongdong Wang,Ruohong Shi,Zhen Guo,Haibao Wang,Qianwang Chen
摘要
Controlled drug release is a promising approach for cancer therapy due to its merits of reduced systemic toxicity and enhanced antitumor efficacy. Here, multifunctional Fe3O4@carbon@zeolitic imidazolate framework-8 (FCZ) hybrid nanoparticles (NPs) were successfully constructed. Owing to the porosity and acid-sensitivity of zeolitic imidazolate framework-8 (ZIF-8), FCZ NPs not only displayed an improved drug loading capacity compared to most of the polymeric nanocarriers, but also exhibited excellent pH-triggered release of doxorubicin (DOX) in vitro. Moreover, carbon dots (CDs) embedded in the porous carbon shell and superparamagnetic iron oxide nanocrystals could simultaneously function as intracellular fluorescence imaging and T2*-weighted magnetic resonance imaging (MRI) contrast agents, respectively. The results obtained from the MTT assay demonstrated good biocompatibility of FCZ NPs. DOX release experiments showed pH regulation-dominated drug release kinetics: a weak acidic pH in tumor areas could trigger sustained drug release, suggesting that FCZ NPs are ideal drug delivery systems. Moreover, the remarkable inhibition of tumor growth without side effects was confirmed in vivo. These results provide convincing evidence establishing the multifunctional FCZ NPs as promising candidates for tumor therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI